Ontology highlight
ABSTRACT:
SUBMITTER: Inoue D
PROVIDER: S-EPMC6545561 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Inoue Daisuke D Obino Dorian D Pineau Judith J Farina Francesca F Gaillard Jérémie J Guerin Christophe C Blanchoin Laurent L Lennon-Duménil Ana-Maria AM Théry Manuel M
The EMBO journal 20190322 11
The centrosome is the main microtubule-organizing centre. It also organizes a local network of actin filaments. However, the precise function of the actin network at the centrosome is not well understood. Here, we show that increasing densities of actin filaments at the centrosome of lymphocytes are correlated with reduced amounts of microtubules. Furthermore, lymphocyte activation resulted in disassembly of centrosomal actin and an increase in microtubule number. To further investigate the dire ...[more]