Ontology highlight
ABSTRACT:
SUBMITTER: Hylton RK
PROVIDER: S-EPMC9068697 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Hylton Ryan K RK Heebner Jessica E JE Grillo Michael A MA Swulius Matthew T MT
Nature communications 20220504 1
Cofilin is best known for its ability to sever actin filaments and facilitate cytoskeletal recycling inside of cells, but at higher concentrations in vitro, cofilin stabilizes a more flexible, hyper-twisted state of actin known as "cofilactin". While this filament state is well studied, a structural role for cofilactin in dynamic cellular processes has not been observed. With a combination of cryo-electron tomography and fluorescence imaging in neuronal growth cones, we observe that filopodial a ...[more]