Bridging the gap between reference and real transcriptomes.
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ABSTRACT:
SUBMITTER: Morillon A
PROVIDER: S-EPMC6545731 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Publications
Bridging the gap between reference and real transcriptomes.
Morillon Antonin A Gautheret Daniel D
Genome biology 20190603 1
Genetic, transcriptional, and post-transcriptional variations shape the transcriptome of individual cells, rendering establishing an exhaustive set of reference RNAs a complicated matter. Current reference transcriptomes, which are based on carefully curated transcripts, are lagging behind the extensive RNA variation revealed by massively parallel sequencing. Much may be missed by ignoring this unreferenced RNA diversity. There is plentiful evidence for non-reference transcripts with important p ...[more]
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