Enhancers: bridging the gap between gene control and human disease.
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ABSTRACT:
SUBMITTER: Karnuta JM
PROVIDER: S-EPMC6061867 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Publications
Enhancers: bridging the gap between gene control and human disease.
Karnuta Jaret M JM Scacheri Peter C PC
Human molecular genetics 20180801 R2
Enhancers are a class of regulatory elements essential for precise spatio-temporal control of gene expression during development and in terminally differentiated cells. This review highlights signature features of enhancer elements as well as new advances that provide mechanistic insights into enhancer-mediated gene control in the context of three-dimensional chromatin. We detail the various ways in which non-coding mutations can instigate aberrant gene control and cause a variety of Mendelian d ...[more]
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