Ontology highlight
ABSTRACT:
SUBMITTER: Sterlin D
PROVIDER: S-EPMC6546332 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Sterlin Delphine D Fieschi Claire C Malphettes Marion M Larsen Martin M Gorochov Guy G Fadlallah Jehane J
Gut microbes 20181118 3
In a recently published article we report the metagenomic analysis of human gut microbiomes evolved in the absence of immunoglobulin A (IgA). We show that human IgA deficiency is not associated with massive quantitative perturbations of gut microbial ecology. While our study underlines a rather expected pathobiont expansion, we at the same time highlight a less expected depletion in some typically beneficial symbionts. We also show that IgM partially supply IgA deficiency, explaining the relativ ...[more]