Ontology highlight
ABSTRACT:
SUBMITTER: Urdinguio RG
PROVIDER: S-EPMC6547425 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Urdinguio Rocio G RG Lopez Virginia V Bayón Gustavo F GF Diaz de la Guardia Rafael R Sierra Marta I MI García-Toraño Estela E Perez Raúl F RF García María G MG Carella Antonella A Pruneda Patricia C PC Prieto Cristina C Dmitrijeva Marija M Santamarina Pablo P Belmonte Thalía T Mangas Cristina C Diaconu Elena E Ferrero Cecilia C Tejedor Juan Ramón JR Fernandez-Morera Juan Luis JL Bravo Cristina C Bueno Clara C Sanjuan-Pla Alejandra A Rodriguez Ramon M RM Suarez-Alvarez Beatriz B López-Larrea Carlos C Bernal Teresa T Colado Enrique E Balbín Milagros M García-Suarez Olivia O Chiara María Dolores MD Sáenz-de-Santa-María Inés I Rodríguez Francisco F Pando-Sandoval Ana A Rodrigo Luis L Santos Laura L Salas Ana A Vallejo-Díaz Jesús J C Carrera Ana A Rico Daniel D Hernández-López Inmaculada I Vayá Amparo A Ricart José M JM Seto Edward E Sima-Teruel Núria N Vaquero Alejandro A Valledor Luis L Cañal Maria Jesus MJ Pisano David D Graña-Castro Osvaldo O Thomas Tim T Voss Anne K AK Menéndez Pablo P Villar-Garea Ana A Deutzmann Rainer R Fernandez Agustín F AF Fraga Mario F MF
Nucleic acids research 20190601 10
Histone H4 acetylation at Lysine 16 (H4K16ac) is a key epigenetic mark involved in gene regulation, DNA repair and chromatin remodeling, and though it is known to be essential for embryonic development, its role during adult life is still poorly understood. Here we show that this lysine is massively hyperacetylated in peripheral neutrophils. Genome-wide mapping of H4K16ac in terminally differentiated blood cells, along with functional experiments, supported a role for this histone post-translati ...[more]