Ontology highlight
ABSTRACT:
SUBMITTER: Geng Y
PROVIDER: S-EPMC6547763 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Nucleic acids research 20190601 10
Human telomeric guanine-rich DNA, which could adopt different G-quadruplex structures, plays important roles in protecting the cell from recombination and degradation. Although many of these structures were determined, the chair-type G-quadruplex structure remains elusive. Here, we present a crystal structure of the G-quadruplex composed of the human telomeric sequence d[GGGTTAGG8GTTAGGGTTAGG20G] with two dG to 8Br-dG substitutions at positions 8 and 20 with syn conformation in the K+ solution. ...[more]