Ontology highlight
ABSTRACT:
SUBMITTER: Campbell HK
PROVIDER: S-EPMC6548143 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Campbell Hannah K HK Salvi Alicia M AM O'Brien Timothy T Superfine Richard R DeMali Kris A KA
The Journal of cell biology 20190402 6
Too little or too much force can trigger cell death, yet factors that ensure the survival of cells remain largely unknown. Here, we demonstrate that E-cadherin responds to force by recruiting and activating p21-activated protein kinase 2 (PAK2) to allow cells to stiffen, metabolize, and survive. Interestingly, PAK2 activation and its control of the apoptotic response are specific for the amplitude of force applied. Specifically, under low amplitudes of physiological force, PAK2 is protected from ...[more]