Ontology highlight
ABSTRACT:
SUBMITTER: Bays JL
PROVIDER: S-EPMC5494977 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Bays Jennifer L JL Campbell Hannah K HK Heidema Christy C Sebbagh Michael M DeMali Kris A KA
Nature cell biology 20170529 6
The response of cells to mechanical force is a major determinant of cell behaviour and is an energetically costly event. How cells derive energy to resist mechanical force is unknown. Here, we show that application of force to E-cadherin stimulates liver kinase B1 (LKB1) to activate AMP-activated protein kinase (AMPK), a master regulator of energy homeostasis. LKB1 recruits AMPK to the E-cadherin mechanotransduction complex, thereby stimulating actomyosin contractility, glucose uptake and ATP pr ...[more]