Ontology highlight
ABSTRACT:
SUBMITTER: Zeng M
PROVIDER: S-EPMC6548289 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Zeng Menglong M Bai Guanhua G Zhang Mingjie M
Small GTPases 20170623 4
SynGAP, encoded by <i>SYNGAP1</i>, is a Ras/Rap GTPase activator specifically expressed in the nervous systems. SynGAP is one of the most abundant proteins in the postsynaptic densities (PSDs) of excitatory synapses and acts as a critical synaptic activity brake by tuning down synaptic GTPase activities. Mutations of <i>SYNGAP1</i> have been frequently linked to brain disorders including intellectual disability, autisms, and seizure. SynGAP has been shown to undergo fast dispersions from synapse ...[more]