Ontology highlight
ABSTRACT:
SUBMITTER: Malay AD
PROVIDER: S-EPMC7673682 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Malay Ali D AD Suzuki Takehiro T Katashima Takuya T Kono Nobuaki N Arakawa Kazuharu K Numata Keiji K
Science advances 20201104 45
Spider silk fiber rapidly assembles from spidroin protein in soluble state via an incompletely understood mechanism. Here, we present an integrated model for silk formation that incorporates the effects of multiple chemical and physical gradients on the different spidroin functional domains. Central to the process is liquid-liquid phase separation (LLPS) that occurs in response to multivalent anions such as phosphate, mediated by the carboxyl-terminal and repetitive domains. Acidification couple ...[more]