Low extracellular magnesium does not impair glucose-stimulated insulin secretion.
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ABSTRACT:
SUBMITTER: Gommers LMM
PROVIDER: S-EPMC6548430 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Low extracellular magnesium does not impair glucose-stimulated insulin secretion.
Gommers Lisanne M M LMM Hill Thomas G TG Ashcroft Frances M FM de Baaij Jeroen H F JHF
PloS one 20190604 6
There is an increasing amount of clinical evidence that hypomagnesemia (serum Mg2+ levels < 0.7 mmol/l) contributes to type 2 diabetes mellitus pathogenesis. Amongst other hypotheses, it has been suggested that Mg2+ deficiency affects insulin secretion. The aim of this study was, therefore, to investigate the acute effects of extracellular Mg2+ on glucose-stimulated insulin secretion in primary mouse islets of Langerhans and the rat insulinoma INS-1 cell line. Here we show that acute lowering of ...[more]
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