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Pannexin-1 channels bridge apoptosis to NLRP3 inflammasome activation.

ABSTRACT: Apoptosis can promote inflammation by triggering activation of the NLRP3 inflammasome (NLR family, pyrin domain containing 3). However, the molecular mechanisms regulating these processes are ill-defined. We recently reported that pannexin-1 is required to promote NLRP3 inflammasome assembly. We further demonstrate that differential cleavage of gasdermin D (GSDMD) by apoptotic caspases regulates inflammatory cell lysis. Here, we discuss our findings and perspectives for future studies.

SUBMITTER: Demarco B

PROVIDER: S-EPMC6548479 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Pannexin-1 channels bridge apoptosis to NLRP3 inflammasome activation.

Demarco Benjamin B Chen Kaiwen W KW Broz Petr P

Molecular & cellular oncology 20190507 4

Apoptosis can promote inflammation by triggering activation of the NLRP3 inflammasome (NLR family, pyrin domain containing 3). However, the molecular mechanisms regulating these processes are ill-defined. We recently reported that pannexin-1 is required to promote NLRP3 inflammasome assembly. We further demonstrate that differential cleavage of gasdermin D (GSDMD) by apoptotic caspases regulates inflammatory cell lysis. Here, we discuss our findings and perspectives for future studies. ...[more]

PMID: 31211242

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