Species specific differences in use of ANP32 proteins by influenza A virus.
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ABSTRACT:
SUBMITTER: Long JS
PROVIDER: S-EPMC6548507 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Publications
Species specific differences in use of ANP32 proteins by influenza A virus.
Long Jason S JS Idoko-Akoh Alewo A Mistry Bhakti B Goldhill Daniel D Staller Ecco E Schreyer Jocelyn J Ross Craig C Goodbourn Steve S Shelton Holly H Skinner Michael A MA Sang Helen H McGrew Michael J MJ Barclay Wendy W
eLife 20190604
Influenza A viruses (IAV) are subject to species barriers that prevent frequent zoonotic transmission and pandemics. One of these barriers is the poor activity of avian IAV polymerases in human cells. Differences between avian and mammalian ANP32 proteins underlie this host range barrier. Human ANP32A and ANP32B homologues both support function of human-adapted influenza polymerase but do not support efficient activity of avian IAV polymerase which requires avian ANP32A. We show here that the ge ...[more]
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