Ontology highlight
ABSTRACT:
SUBMITTER: Poulin EJ
PROVIDER: S-EPMC6548671 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Poulin Emily J EJ Bera Asim K AK Lu Jia J Lin Yi-Jang YJ Strasser Samantha Dale SD Paulo Joao A JA Huang Tannie Q TQ Morales Carolina C Yan Wei W Cook Joshua J Nowak Jonathan A JA Brubaker Douglas K DK Joughin Brian A BA Johnson Christian W CW DeStefanis Rebecca A RA Ghazi Phaedra C PC Gondi Sudershan S Wales Thomas E TE Iacob Roxana E RE Bogdanova Lana L Gierut Jessica J JJ Li Yina Y Engen John R JR Perez-Mancera Pedro A PA Braun Benjamin S BS Gygi Steven P SP Lauffenburger Douglas A DA Westover Kenneth D KD Haigis Kevin M KM
Cancer discovery 20190405 6
<i>KRAS</i> is the most frequently mutated oncogene. The incidence of specific <i>KRAS</i> alleles varies between cancers from different sites, but it is unclear whether allelic selection results from biological selection for specific mutant KRAS proteins. We used a cross-disciplinary approach to compare KRAS<sup>G12D</sup>, a common mutant form, and KRAS<sup>A146T</sup>, a mutant that occurs only in selected cancers. Biochemical and structural studies demonstrated that KRAS<sup>A146T</sup> exhi ...[more]