Ontology highlight
ABSTRACT:
SUBMITTER: Mohan CD
PROVIDER: S-EPMC6548846 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Mohan Chakrabhavi Dhananjaya CD Hari Swetha S Preetham Habbanakuppe D HD Rangappa Shobith S Barash Uri U Ilan Neta N Nayak S Chandra SC Gupta Vijai K VK Basappa Vlodavsky Israel I Rangappa Kanchugarakoppal S KS
iScience 20190503
Heparanase is an endoglycosidase involved in remodeling the extracellular matrix and thereby in regulating multiple cellular processes and biological activities. It cleaves heparan sulfate (HS) side chains of HS proteoglycans into smaller fragments and hence regulates tissue morphogenesis, differentiation, and homeostasis. Heparanase is overexpressed in various carcinomas, sarcomas, and hematological malignancies, and its upregulation correlates with increased tumor size, tumor angiogenesis, enh ...[more]