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PI3K-AKT-Targeting Breast Cancer Treatments: Natural Products and Synthetic Compounds.

ABSTRACT: Breast cancer is the most commonly diagnosed cancer in women. The high incidence of breast cancer, which is continuing to rise, makes treatment a significant challenge. The PI3K-AKT pathway and its downstream targets influence various cellular processes. In recent years, mounting evidence has shown that natural products and synthetic drugs targeting PI3K-AKT signaling have the potential to treat breast cancer. In this review, we discuss the role of the PI3K-AKT signaling pathway in the occurrence and development of breast cancer and highlight PI3K-AKT-targeting natural products and drugs in clinical trials for the treatment of breast cancer.

SUBMITTER: Yuan Y

PROVIDER: S-EPMC9856042 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

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PI3K-AKT-Targeting Breast Cancer Treatments: Natural Products and Synthetic Compounds.

Yuan Yeqin Y Long Huizhi H Zhou Ziwei Z Fu Yuting Y Jiang Binyuan B

Biomolecules 20230102 1

Breast cancer is the most commonly diagnosed cancer in women. The high incidence of breast cancer, which is continuing to rise, makes treatment a significant challenge. The PI3K-AKT pathway and its downstream targets influence various cellular processes. In recent years, mounting evidence has shown that natural products and synthetic drugs targeting PI3K-AKT signaling have the potential to treat breast cancer. In this review, we discuss the role of the PI3K-AKT signaling pathway in the occurrenc ...[more]

PMID: 36671478

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