Ontology highlight
ABSTRACT:
SUBMITTER: Hakansson J
PROVIDER: S-EPMC6548878 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Håkansson Joakim J Ringstad Lovisa L Umerska Anita A Johansson Jenny J Andersson Therese T Boge Lukas L Rozenbaum René T RT Sharma Prashant K PK Tollbäck Petter P Björn Camilla C Saulnier Patrick P Mahlapuu Margit M
Frontiers in cellular and infection microbiology 20190528
Antimicrobial peptides, also known as host defense peptides, have recently emerged as a promising new category of therapeutic agents for the treatment of infectious diseases. This study evaluated the preclinical <i>in vitro, ex vivo</i>, and <i>in vivo</i> antimicrobial activity, as well as the potential to cause skin irritation, of human kininogen-derived antimicrobial peptide DPK-060 in different formulations designed for topical delivery. We found that DPK-060 formulated in acetate buffer or ...[more]