Ontology highlight
ABSTRACT:
SUBMITTER: Wong EB
PROVIDER: S-EPMC6549148 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Communications biology 20190605
Mucosal-associated invariant T (MAIT) cells typically express a TRAV1-2<sup>+</sup> semi-invariant TCRα that enables recognition of bacterial, mycobacterial, and fungal riboflavin metabolites presented by MR1. MAIT cells are associated with immune control of bacterial and mycobacterial infections in murine models. Here, we report that a population of pro-inflammatory TRAV1-2<sup>+</sup> CD8<sup>+</sup> T cells are present in the airways and lungs of healthy individuals and are enriched in bronch ...[more]