Ontology highlight
ABSTRACT:
SUBMITTER: Herrlinger S
PROVIDER: S-EPMC6550015 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Herrlinger Stephanie S Shao Qiang Q Yang Mei M Chang Qing Q Liu Yang Y Pan Xiaohan X Yin Hang H Xie Li-Wei LW Chen Jian-Fu JF
Development (Cambridge, England) 20190528 10
Neural progenitor cells (NPCs) undergo rapid proliferation during neurulation. This rapid growth generates a high demand for mRNA translation in a timing-dependent manner, but its underlying mechanism remains poorly understood. Lin28 is an RNA-binding protein with two paralogs, Lin28a and Lin28b, in mammals. Mice with <i>Lin28b</i> deletion exhibit no developmental defects, whereas we have previously reported that <i>Lin28a</i> deletion leads to microcephaly. Here, we find that <i>Lin28a/b</i> d ...[more]