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A new densovirus in cerebrospinal fluid from a case of anti-NMDA-receptor encephalitis.

ABSTRACT: We characterized the genome of a densovirus, tentatively called human CSF-associated densovirus 1 (HuCSFDV1), in cerebrospinal fluid (CSF) from a human case of encephalitis with antibodies against the N-methyl D-aspartate receptor. The presence of the viral genome in CSF was independently confirmed. This virus, which is proposed to be a member of a new species in the genus Iteradensovirus of the subfamily Densovirinae, showed the typical two ORFs encoding nonstructural and structural proteins with low-level identities of 22 and 16 % to the closest known densovirus relative. No other eukaryotic viral sequences were detected using deep sequencing. The replication and pathogenicity in humans of this virus, which belongs to a viral subfamily whose members are only known to replicate in invertebrates, remain to be demonstrated. Alternative explanations for the detection of densovirus DNA in CSF are discussed.

SUBMITTER: Phan TG

PROVIDER: S-EPMC6550996 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature

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A new densovirus in cerebrospinal fluid from a case of anti-NMDA-receptor encephalitis.

Phan Tung Gia TG Messacar Kevin K Dominguez Samuel R SR da Costa Antonio Charlys AC Deng Xutao X Delwart Eric E

Archives of virology 20160813 11

We characterized the genome of a densovirus, tentatively called human CSF-associated densovirus 1 (HuCSFDV1), in cerebrospinal fluid (CSF) from a human case of encephalitis with antibodies against the N-methyl D-aspartate receptor. The presence of the viral genome in CSF was independently confirmed. This virus, which is proposed to be a member of a new species in the genus Iteradensovirus of the subfamily Densovirinae, showed the typical two ORFs encoding nonstructural and structural proteins wi ...[more]

PMID: 27522586

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