Ontology highlight
ABSTRACT:
SUBMITTER: Dahlgren MW
PROVIDER: S-EPMC6553479 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Dahlgren Madelene W MW Jones Stephen W SW Cautivo Kelly M KM Dubinin Alexandra A Ortiz-Carpena Jorge F JF Farhat Sepideh S Yu Kevin S KS Lee Katharine K Wang Chaoqun C Molofsky Anna V AV Tward Aaron D AD Krummel Matthew F MF Peng Tien T Molofsky Ari B AB
Immunity 20190226 3
Type 2 lymphocytes promote both physiologic tissue remodeling and allergic pathology, yet their physical tissue niches are poorly described. Here, we used quantitative imaging to define the tissue niches of group 2 innate lymphoid cells (ILC2s), which are critical instigators of type 2 immunity. We identified a dominant adventitial niche around lung bronchi and larger vessels in multiple tissues, where ILC2s localized with subsets of dendritic and regulatory T cells. However, ILC2s were most int ...[more]