Ontology highlight
ABSTRACT:
SUBMITTER: Wang H
PROVIDER: S-EPMC6646407 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Wang Hongdong H Shen Lei L Sun Xitai X Liu Fangcen F Feng Wenhuan W Jiang Chunping C Chu Xuehui X Ye Xiao X Jiang Can C Wang Yan Y Zhang Pengzi P Zang Mengwei M Zhu Dalong D Bi Yan Y
Nature communications 20190722 1
Pathogenic factors driving obesity to type 2 diabetes (T2D) are not fully understood. Group 1 innate lymphoid cells (ILC1s) are effectors of innate immunity and enriched in inflamed tissues. Here we show that the number of adipose ILC1s increases in obese T2D patients and correlates with glycemic parameters and with the number of ILC1s in the blood; circulating ILC1 numbers decrease as a result of metabolic improvements after bariatric surgery. In vitro co-culture experiments show that human adi ...[more]