Ontology highlight
ABSTRACT:
SUBMITTER: Knowles DA
PROVIDER: S-EPMC6555538 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Knowles David A DA Bouchard Gina G Plevritis Sylvia S
PLoS computational biology 20190528 5
Drug screening studies typically involve assaying the sensitivity of a range of cancer cell lines across an array of anti-cancer therapeutics. Alongside these sensitivity measurements high dimensional molecular characterizations of the cell lines are typically available, including gene expression, copy number variation and genomic mutations. We propose a sparse multitask regression model which learns discriminative latent characteristics that predict drug sensitivity and are associated with spec ...[more]