Ontology highlight
ABSTRACT:
SUBMITTER: Kim Y
PROVIDER: S-EPMC6834616 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Kim Yongsoo Y Bismeijer Tycho T Zwart Wilbert W Wessels Lodewyk F A LFA Vis Daniel J DJ
Nature communications 20191106 1
Integrative analyses that summarize and link molecular data to treatment sensitivity are crucial to capture the biological complexity which is essential to further precision medicine. We introduce Weighted Orthogonal Nonnegative parallel factor analysis (WON-PARAFAC), a data integration method that identifies sparse and interpretable factors. WON-PARAFAC summarizes the GDSC1000 cell line compendium in 130 factors. We interpret the factors based on their association with recurrent molecular alter ...[more]