Ontology highlight
ABSTRACT:
SUBMITTER: Ho CM
PROVIDER: S-EPMC6555636 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Ho Chi-Min CM Beck Josh R JR Lai Mason M Cui Yanxiang Y Goldberg Daniel E DE Egea Pascal F PF Zhou Z Hong ZH
Nature 20180827 7721
The putative Plasmodium translocon of exported proteins (PTEX) is essential for transport of malarial effector proteins across a parasite-encasing vacuolar membrane into host erythrocytes, but the mechanism of this process remains unknown. Here we show that PTEX is a bona fide translocon by determining structures of the PTEX core complex at near-atomic resolution using cryo-electron microscopy. We isolated the endogenous PTEX core complex containing EXP2, PTEX150 and HSP101 from Plasmodium falci ...[more]