CHML promotes liver cancer metastasis by facilitating Rab14 recycle.
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ABSTRACT:
SUBMITTER: Chen TW
PROVIDER: S-EPMC6555802 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Publications
CHML promotes liver cancer metastasis by facilitating Rab14 recycle.
Chen Tian-Wei TW Yin Fen-Fen FF Yuan Yan-Mei YM Guan Dong-Xian DX Zhang Erbin E Zhang Feng-Kun FK Jiang Hao H Ma Ning N Wang Jing-Jing JJ Ni Qian-Zhi QZ Qiu Lin L Feng Jing J Zhang Xue-Li XL Bao Ying Y Wang Kang K Cheng Shu-Qun SQ Wang Xiao-Fan XF Wang Xiang X Li Jing-Jing JJ Xie Dong D
Nature communications 20190607 1
Metastasis-associated recurrence is the major cause of poor prognosis in hepatocellular carcinoma (HCC), however, the underlying mechanisms remain largely elusive. In this study, we report that expression of choroideremia-like (CHML) is increased in HCC, associated with poor survival, early recurrence and more satellite nodules in HCC patients. CHML promotes migration, invasion and metastasis of HCC cells, in a Rab14-dependent manner. Mechanism study reveals that CHML facilitates constant recycl ...[more]
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