Ontology highlight
ABSTRACT:
SUBMITTER: Nakano Y
PROVIDER: S-EPMC6556397 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Cell reports 20190401 3
A truncating mutation in the mouse Srrm4 gene, which encodes a neuronal splicing factor, causes alternative splicing defects selectively in the ear. The mechanism by which splicing is preserved in the brain of these mice is not known. Here, we show that SRRM3 limits the Srrm4 mutation-associated defects to the ear and that, in cortical neurons, overlapping SRRM3-SRRM4 activity regulates the development of interneuronal inhibition. In vitro, SRRM3 and SRRM4 regulate the same splicing events, but ...[more]