Current status of small molecule drug development for Ebola virus and other filoviruses.
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ABSTRACT:
SUBMITTER: Edwards MR
PROVIDER: S-EPMC6556423 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Publications
Current status of small molecule drug development for Ebola virus and other filoviruses.
Edwards Megan R MR Basler Christopher F CF
Current opinion in virology 20190416
The filovirus family includes some of the deadliest viruses known, including Ebola virus and Marburg virus. These viruses cause periodic outbreaks of severe disease that can be spread from person to person, making the filoviruses important public health threats. There remains a need for approved drugs that target all or most members of this virus family. Small molecule inhibitors that target conserved functions hold promise as pan-filovirus therapeutics. To date, compounds that effectively targe ...[more]
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