Dataset Information

Relationship between circulating concentration of Ang II, ADM and ADT and left ventricular hypertrophy in hypertension.

ABSTRACT:

Background

Left ventricular hypertrophy (LVH) is the most common structural damage in hypertensive complication and is an independent risk factor for assessing cardiovascular events. The aim of this study was explore the relationship between plasma concentration of angiotensin II (Ang II), Adrenomedulin (ADM) and adrenotensin (ADT) in patients with hypertension and LVH.

Methods

We enrolled 310 hypertensive patients from the department of cardiology of Tianjin Union Medical Center as the hypertension group and 39 healthy subjects as control group. Further grouping according to the LVMI (male LVMI?115 g/m², female LVMI?95 g/m²) values for determining LVH in the 2013 ESC Hypertension Management Guidelines. Plasma levels of Ang II, ADM and ADT were measured using ELISA assay.

Results

The levels of plasma Ang II and ADM in essential hypertension (EH) were significantly higher than control group, and the essential hypertension combined left ventricular hypertrophy (EHCLVH) group was higher than essential hypertension not with left ventricular hypertrophy (EHNLVH) group (P<0.05). Correlation analyze showed that left ventricular mass index (LVMI) was positively related to Ang II and ADM, and negatively related to ADT. Logistic regression analyze indicated that LVH are strongly linked with systolic blood pressure (SBP), Ang II, ADM and ADT. ROC curve showed ADM and ADT have similar value in distinguish LVH.

Conclusion

Plasma levels of Ang II, ADM and ADT might act as indicator to identify hypertensive LVH.

SUBMITTER: Cui Y

PROVIDER: S-EPMC6556659 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Relationship between circulating concentration of Ang II, ADM and ADT and left ventricular hypertrophy in hypertension.

Cui Yameng Y Zhu Zhenyu Z Qi Xin X Li Huihui H Wu Yulin Y Chen Wanli W Liu Yue Y

American journal of translational research 20190515 5

<h4>Background</h4>Left ventricular hypertrophy (LVH) is the most common structural damage in hypertensive complication and is an independent risk factor for assessing cardiovascular events. The aim of this study was explore the relationship between plasma concentration of angiotensin II (Ang II), Adrenomedulin (ADM) and adrenotensin (ADT) in patients with hypertension and LVH.<h4>Methods</h4>We enrolled 310 hypertensive patients from the department of cardiology of Tianjin Union Medical Center ...[more]

PMID: 31217886

Similar Datasets

Project description:BackgroundLeft ventricular hypertrophy (LVH) strongly predicts cardiovascular diseases (CVD) and death. One-fourth of Thai adults suffer from hypertension. Nevertheless, the information on LVH among Thai patients with hypertension is not well characterized. We aimed to identify the prevalence and factors associated with electrocardiographic LVH (ECG-LVH) among patients with hypertension in Thailand.MethodsThe present study obtained the dataset from the Thailand Diabetes Mellitus/Hypertension study, which included hypertension patients aged 20 years and older receiving continuous care at outpatient clinics in hospitals nationwide in 2011-2015 and 2018. Meanwhile, those without a record of 12-lead electrocardiography (ECG) were excluded from the analysis. ECG-LVH was defined as the LVH noted regarding ECG interpretation in the medical records. Multivariable logistic regression analysis was utilized for determining factors associated with ECG-LVH and presented as the adjusted odds ratio (AOR) and 95% confidence interval (CI).ResultsFrom 226,420 hypertensive patients in the Thailand Diabetes Mellitus/Hypertension study, 38,807 individuals (17.1%) with ECG data recorded were included in the analysis. The mean age was 64.8 ± 11.5 years, and 62.2% were women. Overall, 1,557 study participants had ECG-LVH, with an estimated prevalence of 4.0% (95% CI, 3.8-4.2%). Age-adjusted ECG-LVH prevalence among women and men was 3.4 and 5.1%, respectively (P < 0.001). Multivariable analysis determined factors associated with ECG-LVH, including being men (AOR, 1.49; 95% CI, 1.31-1.69), individuals aged 70 to 79 years (AOR, 1.56; 95% CI, 1.20-2.02) and ≥ 80 years (AOR, 2.10; 95% CI, 1.58-2.78) compared to individuals aged less than 50 years, current smokers (AOR, 1.26; 95% CI, 1.09-1.46) compared to those who never smoked, systolic blood pressure ≥ 140 mmHg and diastolic blood pressure ≥ 90 mmHg (AOR, 1.58; 95% CI, 1.30-1.92) compared to systolic blood pressure < 140 mmHg and diastolic blood pressure < 90 mmHg.ConclusionsThe current study illustrated the prevalence of ECG-LVH among Thai patients with hypertension who had ECG recorded and identified high-risk groups who tended to have ECG-LVH. The findings underscore the need for targeted interventions, particularly among high-risk groups such as older individuals, men, and current smokers, to address modifiable factors associated with ECG-LVH.

Dataset Information

Relationship between circulating concentration of Ang II, ADM and ADT and left ventricular hypertrophy in hypertension.

Background

Methods

Results

Conclusion

Publications

Relationship between circulating concentration of Ang II, ADM and ADT and left ventricular hypertrophy in hypertension.

Similar Datasets

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