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Low-grade albuminuria in pulmonary arterial hypertension.

ABSTRACT: Low-grade albuminuria, determined by the urinary albumin to creatinine ratio, has been linked to systemic vascular dysfunction and is associated with cardiovascular mortality. Pulmonary arterial hypertension is related to mutations in the bone morphogenetic protein receptor type 2, pulmonary vascular dysfunction and is increasingly recognized as a systemic disease. In a total of 283 patients (two independent cohorts) diagnosed with pulmonary arterial hypertension, 18 unaffected BMPR2 mutation carriers and 68 healthy controls, spot urinary albumin to creatinine ratio and its relationship to demographic, functional, hemodynamic and outcome data were analyzed. Pulmonary arterial hypertension patients and unaffected BMPR2 mutation carriers had significantly elevated urinary albumin to creatinine ratios compared with healthy controls ( P?

SUBMITTER: Nickel NP

PROVIDER: S-EPMC6557031 | biostudies-literature | 2019 Apr-Jun

REPOSITORIES: biostudies-literature

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Low-grade albuminuria in pulmonary arterial hypertension.

Nickel Nils P NP de Jesus Perez Vinicio A VA Zamanian Roham T RT Fessel Joshua P JP Cogan Joy D JD Hamid Rizwam R West James D JD de Caestecker Mark P MP Yang Haichun H Austin Eric D ED

Pulmonary circulation 20190401 2

Low-grade albuminuria, determined by the urinary albumin to creatinine ratio, has been linked to systemic vascular dysfunction and is associated with cardiovascular mortality. Pulmonary arterial hypertension is related to mutations in the bone morphogenetic protein receptor type 2, pulmonary vascular dysfunction and is increasingly recognized as a systemic disease. In a total of 283 patients (two independent cohorts) diagnosed with pulmonary arterial hypertension, 18 unaffected BMPR2 mutation ca ...[more]

PMID: 30632900

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