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Heart ventricles proteomic profile in pulmonary arterial hypertension

ABSTRACT: Arterial pulmonary hypertension is a rare disease, with little knowledge regarding its etiology, and high mortality. Development of right and later on also left ventricular heart insufficiency, secondary to pulmonary hypertension, is a negative predictive factor. Genetic and molecular processes underlying left heart ventricle remodeling over the course of pulmonary hypertension remain unknown. In particular, there is no knowledge regarding the mechanisms of left heart ventricle atrophy which was completely avoided by researchers until recently.The aim of this study was to assess changes in protein abundance in left and right heart ventricle free wall of rats in monocrotaline model of PAH.

INSTRUMENT(S): Velos Plus

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Heart

DISEASE(S): Pulmonary Hypertension

SUBMITTER: Maciej Suski

LAB HEAD: Rafał Olszanecki

PROVIDER: PXD015896 | Pride | 2020-09-07

REPOSITORIES: pride

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			Action	DRS
	15MK1L.raw	Raw
	15MK1L.tandem.pep.xml	Pepxml
	15MK1L_B.raw	Raw
	15MK1L_B.tandem.pep.xml	Pepxml
	15MK1L_B_comet.pep.xml	Pepxml

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Myocardial proteomic profile in pulmonary arterial hypertension.

Hołda Mateusz K MK Stachowicz Aneta A Suski Maciej M Wojtysiak Dorota D Sowińska Natalia N Arent Zbigniew Z Palka Natalia N Podolec Piotr P Kopeć Grzegorz G

Scientific reports 20200901 1

Pulmonary arterial hypertension (PAH) is a rare, fatal, and incurable disorder. Although advances in the understanding of the PAH pathobiology have been seen in recent years, molecular processes underlying heart remodelling over the course of PAH are still insufficiently understood. Therefore, the aim of this study was to investigate myocardial proteomic profile of rats at different stages of monocrotaline-induced PAH. Samples of left and right ventricle (LV and RV) free wall collected from 32 W ...[more]

PMID: 32873862

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