Ontology highlight
ABSTRACT:
SUBMITTER: Nassour J
PROVIDER: S-EPMC6557118 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Nassour Joe J Radford Robert R Correia Adriana A Fusté Javier Miralles JM Schoell Brigitte B Jauch Anna A Shaw Reuben J RJ Karlseder Jan J
Nature 20190123 7741
Replicative crisis is a senescence-independent process that acts as a final barrier against oncogenic transformation by eliminating pre-cancerous cells with disrupted cell cycle checkpoints<sup>1</sup>. It functions as a potent tumour suppressor and culminates in extensive cell death. Cells rarely evade elimination and evolve towards malignancy, but the mechanisms that underlie cell death in crisis are not well understood. Here we show that macroautophagy has a dominant role in the death of fibr ...[more]