Ontology highlight
ABSTRACT:
SUBMITTER: Nguyen CDK
PROVIDER: S-EPMC6557283 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Nguyen Chan D K CDK Yi Chunling C
Trends in cancer 20190327 5
Drug resistance is a major challenge in cancer treatment. Emerging evidence indicates that deregulation of YAP/TAZ signaling may be a major mechanism of intrinsic and acquired resistance to various targeted and chemotherapies. Moreover, YAP/TAZ-mediated expression of PD-L1 and multiple cytokines is pivotal for tumor immune evasion. While direct inhibitors of YAP/TAZ are still under development, FDA-approved drugs that indirectly block YAP/TAZ activation or critical downstream targets of YAP/TAZ ...[more]