Ontology highlight
ABSTRACT:
SUBMITTER: Wong JH
PROVIDER: S-EPMC6557514 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Wong Jin Huei JH Alfatah Mohammad M Kong Kiat Whye KW Hoon Shawn S Yeo Wan Lin WL Ching Kuan Chieh KC Jie Hui Goh Corinna C Zhang Mingzi M MM Lim Yee Hwee YH Wong Fong Tian FT Arumugam Prakash P
PloS one 20190610 6
In this study, we report antifungal activity of auroramycin against Candida albicans, Candida tropicalis, and Cryptococcus neoformans. Auroramycin, a potent antimicrobial doubly glycosylated 24-membered polyene macrolactam, was previously isolated and characterized, following CRISPR-Cas9 mediated activation of a silent polyketide synthase biosynthetic gene cluster in Streptomyces rosesporous NRRL 15998. Chemogenomic profiling of auroramycin in yeast has linked its antifungal bioactivity to vacuo ...[more]