Chemogenomic profiling predicts antifungal synergies.
Ontology highlight
ABSTRACT:
SUBMITTER: Jansen G
PROVIDER: S-EPMC2824495 | biostudies-other | 2009
REPOSITORIES: biostudies-other
Publications
Chemogenomic profiling predicts antifungal synergies.
Jansen Gregor G Lee Anna Y AY Epp Elias E Fredette Amélie A Surprenant Jamie J Harcus Doreen D Scott Michelle M Tan Elaine E Nishimura Tamiko T Whiteway Malcolm M Hallett Michael M Thomas David Y DY
Molecular systems biology 20091222
Chemotherapies, HIV infections, and treatments to block organ transplant rejection are creating a population of immunocompromised individuals at serious risk of systemic fungal infections. Since single-agent therapies are susceptible to failure due to either inherent or acquired resistance, alternative therapeutic approaches such as multi-agent therapies are needed. We have developed a bioinformatics-driven approach that efficiently predicts compound synergy for such combinatorial therapies. The ...[more]
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