Ontology highlight
ABSTRACT:
SUBMITTER: Christensen JR
PROVIDER: S-EPMC6557641 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Christensen Jenna R JR Homa Kaitlin E KE Morganthaler Alisha N AN Brown Rachel R RR Suarez Cristian C Harker Alyssa J AJ O'Connell Meghan E ME Kovar David R DR
eLife 20190610
We previously discovered that competition between fission yeast actin binding proteins (ABPs) for binding F-actin facilitates their sorting to different cellular networks. Specifically, competition between endocytic actin patch ABPs fimbrin Fim1 and cofilin Adf1 enhances their activities, and prevents tropomyosin Cdc8's association with actin patches. However, these interactions do not explain how Fim1 is prevented from associating strongly with other F-actin networks such as the contractile rin ...[more]