Ontology highlight
ABSTRACT:
SUBMITTER: Viscoli CM
PROVIDER: S-EPMC6557695 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Viscoli Catherine M CM Kent David M DM Conwit Robin R Dearborn Jennifer L JL Furie Karen L KL Gorman Mark M Guarino Peter D PD Inzucchi Silvio E SE Stuart Amber A Young Lawrence H LH Kernan Walter N WN
Stroke 20181210 1
Background and Purpose- The insulin sensitizer, pioglitazone, reduces cardiovascular risk in patients after an ischemic stroke or transient ischemic attack but increases bone fracture risk. We conducted a secondary analysis of the IRIS trial (Insulin Resistance Intervention After Stroke) to assess the effect of pretreatment risk for fracture on the net benefits of pioglitazone therapy. Methods- IRIS was a randomized placebo-controlled trial of pioglitazone that enrolled patients with insulin res ...[more]