Ontology highlight
ABSTRACT:
SUBMITTER: Saraiva C
PROVIDER: S-EPMC6558030 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Saraiva Cláudia C Barata-Antunes Sandra S Santos Tiago T Ferreiro Elisabete E Cristóvão Ana Clara AC Serra-Almeida Catarina C Ferreira Raquel R Bernardino Liliana L
Scientific reports 20190610 1
Evidence points to a dual role of histamine in microglia-mediated neuroinflammation, a key pathological feature of several neurodegenerative pathologies. Moreover, histamine has been suggested as a modulator of adult neurogenesis. Herein, we evaluated the effect of histamine in hippocampal neuroinflammation and neurogenesis under physiological and inflammatory contexts. For that purpose, mice were intraperitoneally challenged with lipopolysaccharide (LPS) followed by an intrahippocampal injectio ...[more]