Identifying and targeting cancer-specific metabolism with network-based drug target prediction.

ABSTRACT:

Background

Metabolic rewiring allows cancer cells to sustain high proliferation rates. Thus, targeting only the cancer-specific cellular metabolism will safeguard healthy tissues.

Methods

We developed the very efficient FASTCORMICS RNA-seq workflow (rFASTCORMICS) to build 10,005 high-resolution metabolic models from the TCGA dataset to capture metabolic rewiring strategies in cancer cells. Colorectal cancer (CRC) was used as a test case for a repurposing workflow based on rFASTCORMICS.

Findings

Alternative pathways that are not required for proliferation or survival tend to be shut down and, therefore, tumours display cancer-specific essential genes that are significantly enriched for known drug targets. We identified naftifine, ketoconazole, and mimosine as new poten

SUBMITTER: Pacheco MP 

PROVIDER: S-EPMC6558238 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature