Ontology highlight
ABSTRACT:
SUBMITTER: Dijkstra KK
PROVIDER: S-EPMC6558289 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Dijkstra Krijn K KK Cattaneo Chiara M CM Weeber Fleur F Chalabi Myriam M van de Haar Joris J Fanchi Lorenzo F LF Slagter Maarten M van der Velden Daphne L DL Kaing Sovann S Kelderman Sander S van Rooij Nienke N van Leerdam Monique E ME Depla Annekatrien A Smit Egbert F EF Hartemink Koen J KJ de Groot Rosa R Wolkers Monika C MC Sachs Norman N Snaebjornsson Petur P Monkhorst Kim K Haanen John J Clevers Hans H Schumacher Ton N TN Voest Emile E EE
Cell 20180809 6
Cancer immunotherapies have shown substantial clinical activity for a subset of patients with epithelial cancers. Still, technological platforms to study cancer T-cell interactions for individual patients and understand determinants of responsiveness are presently lacking. Here, we establish and validate a platform to induce and analyze tumor-specific T cell responses to epithelial cancers in a personalized manner. We demonstrate that co-cultures of autologous tumor organoids and peripheral bloo ...[more]