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Immune checkpoint blockade and CAR-T cell therapy in hematologic malignancies.

ABSTRACT: Harnessing the power of the immune system to recognize and eliminate cancer cells is a longtime exploration. In the past decade, monoclonal antibody (mAb)-based immune checkpoint blockade (ICB) and chimeric antigen receptor T (CAR-T) cell therapy have proven to be safe and effective in hematologic malignancies. Despite the unprecedented success of ICB and CAR-T therapy, only a subset of patients can benefit partially due to immune dysfunction and lack of appropriate targets. Here, we review the preclinical and clinical advances of CTLA-4 and PD-L1/PD-1-based ICB and CD19-specific CAR-T cell therapy in hematologic malignancies. We also discuss the basic research and ongoing clinical trials on emerging immune checkpoints (Galectin-9/Tim-3, CD70/CD27, LAG-3, and LILRBs) and on new targets for CAR-T cell therapy (CD22, CD33, CD123, BCMA, CD38, and CD138) for the treatment of hematologic malignancies.

SUBMITTER: Wang H

PROVIDER: S-EPMC6558778 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Immune checkpoint blockade and CAR-T cell therapy in hematologic malignancies.

Wang Hao H Kaur Gurbakhash G Sankin Alexander I AI Chen Fuxiang F Guan Fangxia F Zang Xingxing X

Journal of hematology & oncology 20190611 1

Harnessing the power of the immune system to recognize and eliminate cancer cells is a longtime exploration. In the past decade, monoclonal antibody (mAb)-based immune checkpoint blockade (ICB) and chimeric antigen receptor T (CAR-T) cell therapy have proven to be safe and effective in hematologic malignancies. Despite the unprecedented success of ICB and CAR-T therapy, only a subset of patients can benefit partially due to immune dysfunction and lack of appropriate targets. Here, we review the ...[more]

PMID: 31186046

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