Dose deformation-invariance in adaptive prostate radiation therapy: implication for treatment simulations.

ABSTRACT:

Purpose

To investigate dose deformation-invariance in adaptive prostate radiation treatment.

Methods

A 19 patient prostate cancer-cohort with 8-13 CTs/patient is used. The 79.2 Gy plans are developed on the reference image using seven 6 and 18 MV intensity-modulated beams with identical RTOG 0126 objectives. Dose on the subsequent images is evaluated in two ways: (A1) Dose is recalculated on each image. (A2) The initially planned dose distribution is copied to each image. A2 assumes dose-invariance in the accelerator-coordinate-system. Effects of patient miss-alignment are simulated by 27 per-patient image shifts; 0 and ±10 mm in left-right, anterior-posterior and superior-inferior directions. The per-voxel dose differences for each patient image, total accumulated patient d

SUBMITTER: Sharma M 

PROVIDER: S-EPMC6559364 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature