Ontology highlight
ABSTRACT:
SUBMITTER: Teng X
PROVIDER: S-EPMC9708914 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Teng Xinyu X Sheng Danqi D Wang Jin J Yu Ye Y Hattori Motoyuki M
iScience 20221113 12
MgtE is a Mg<sup>2+</sup>-selective ion channel whose orthologs are widely distributed from prokaryotes to eukaryotes, including humans, and are important participants in the maintenance of cellular Mg<sup>2+</sup> homeostasis. The previous high-resolution structure determination of the MgtE transmembrane (TM) domain in complex with Mg<sup>2+</sup> ions revealed a recognition mechanism of MgtE for Mg<sup>2+</sup> ions. In contrast, the previous Ca<sup>2+</sup>-bound structure of the MgtE TM doma ...[more]