Ontology highlight
ABSTRACT:
SUBMITTER: Song Z
PROVIDER: S-EPMC6561217 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20190514 22
Ribozymes synthesize proteins in a highly regulated local environment to minimize side reactions caused by various competing species. In contrast, it is challenging to prepare synthetic polypeptides from the polymerization of <i>N</i>-carboxyanhydrides (NCAs) in the presence of water and impurities, which induce monomer degradations and chain terminations, respectively. Inspired by natural protein synthesis, we herein report the preparation of well-defined polypeptides in the presence of competi ...[more]