Ontology highlight
ABSTRACT:
SUBMITTER: Wang D
PROVIDER: S-EPMC6561918 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Wang Dezhong D Jin Mengyun M Zhao Xinyu X Zhao Tianyang T Lin Wei W He Zhengle Z Fan Miaojuan M Jin Wei W Zhou Jie J Jin Lingwei L Zheng Chao C Jin Hui H Zhao Yushuo Y Li Xiaokun X Ying Lei L Wang Yang Y Zhu Guanghui G Huang Zhifeng Z
Cell death & disease 20190612 6
Currently, there is a lack of effective therapeutic approaches to the treatment of chronic kidney disease (CKD) with irreversible deterioration of renal function. This study aimed to investigate the ability of mutant FGF1 (FGF1<sup>ΔHBS</sup>, which has reduced mitogenic activity) to alleviate CKD and to study its associated mechanisms. We found that FGF1<sup>ΔHBS</sup> exhibited much weaker mitogenic activity than wild-type FGF1 (FGF1<sup>WT</sup>) in renal tissues. RNA-seq analysis revealed th ...[more]