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Three new ent-abietane diterpenoids from the roots of Euphorbia fischeriana and their cytotoxicity in human tumor cell lines.


ABSTRACT: Three new ent-abietane diterpenoids, termed fischerianoids A-C (1-3), were isolated and identified from the ethyl acetate extracts of roots of the medicinally valuable plant Euphorbia fischeriana. The planar and relative structures of 1-3 were established via high-resolution electrospray ionisation mass spectrometry and one- and two-dimensional nuclear magnetic resonance spectroscopic analyses, and the absolute configuration of 1 was further established via X-ray crystallography experiment. Compounds 1-3 showed selective inhibitory potency against certain human tumor cell lines with IC50 values ranging from 8.50?±?0.13 to 35.52?±?0.08 ?M.

SUBMITTER: Li M 

PROVIDER: S-EPMC6562045 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Three new ent-abietane diterpenoids from the roots of Euphorbia fischeriana and their cytotoxicity in human tumor cell lines.

Li Minghui M   He Fang F   Zhou Yuan Y   Wang Meigui M   Tao Pingde P   Tu Qingmei Q   Lv Guanghui G   Chen Xintao X  

Archives of pharmacal research 20190417 6


Three new ent-abietane diterpenoids, termed fischerianoids A-C (1-3), were isolated and identified from the ethyl acetate extracts of roots of the medicinally valuable plant Euphorbia fischeriana. The planar and relative structures of 1-3 were established via high-resolution electrospray ionisation mass spectrometry and one- and two-dimensional nuclear magnetic resonance spectroscopic analyses, and the absolute configuration of 1 was further established via X-ray crystallography experiment. Comp  ...[more]

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