Abietane Diterpernoids from the Roots of Euphorbia ebracteolata.

ABSTRACT: A new ent-abietane diterpernoid, named ebracteolata D (1), along with 11 known analogues, was isolated from the roots of Euphorbia ebracteolata Hayata. The structure of 1 was elucidated on the basis of spectroscopic analysis and molecular modeling. Cytotoxicity of compounds 1-12 was evaluated as well as the effect on the NF-?B pathway. Among them, compound 12, jolkinolide B, displayed broad inhibitory effects against proliferation of tumor cell lines. Mechanistic studies indicated that the compound 12 can inhibit TNF-? induced NF-?B activation, thereby inducing tumor cell apoptosis.

SUBMITTER: Ma YL 

PROVIDER: S-EPMC5913052 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature