Characteristics of an alternative antibacterial biomaterial for mouthwash in the absence of alcohol.
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ABSTRACT: Background/purpose
The purpose of this study was to investigate whether poly-gamma-glutamic acid (?-PGA), a naturally derived biomaterial, was suitable as an alternative antibacterial mouthwash in the absence of alcohol.Materials and methods
Three bacterial strains, Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa, were used for testing the antibacterial activity of mouthwashes. In addition, cell viability, cytotoxicity, and genotoxicity experiments were conducted for testing the toxicity of mouthwashes.Results
We demonstrated that 10000?ppm of ?-PGA without alcohol could efficiently inhibit 99% of bacterial growth. In addition, ?-PGA did not cause any cytotoxicity or genotoxicity.Conclusion
10000?ppm of ?-PGA in an alcohol-free mouthwash is an alternative biomaterial for mouthwashes.
SUBMITTER: Su CY
PROVIDER: S-EPMC6562063 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Publications
Characteristics of an alternative antibacterial biomaterial for mouthwash in the absence of alcohol.
Su Chen-Ying CY Chen Chia-Chun CC Chen Hsuan-Yu HY Lin Chun-Pin CP Lin Feng-Huei FH Fang Hsu-Wei HW
Journal of dental sciences 20190322 2
<h4>Background/purpose</h4>The purpose of this study was to investigate whether poly-gamma-glutamic acid (γ-PGA), a naturally derived biomaterial, was suitable as an alternative antibacterial mouthwash in the absence of alcohol.<h4>Materials and methods</h4>Three bacterial strains, <i>Escherichia coli</i>, <i>Staphylococcus aureus</i>, and <i>Pseudomonas aeruginosa</i>, were used for testing the antibacterial activity of mouthwashes. In addition, cell viability, cytotoxicity, and genotoxicity ex ...[more]
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