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Two New Spiro-Heterocyclic ?-Lactams from A Marine-Derived Aspergillus fumigatus Strain CUGBMF170049.

ABSTRACT: Two new spiro-heterocyclic ?-lactam derivatives, cephalimysins M (1) and N (2), were isolated from the fermentation cultures of the marine-derived fungus Aspergillus fumigatus CUGBMF17018. Two known analogues, pseurotin A (3) and FD-838 (4), as well as four previously reported helvolic acid derivatives, 16-O-propionyl-16-O-deacetylhelvolic acid (5), 6-O-propionyl-6-O-deacetylhelvolic acid (6), helvolic acid (7), and 1,2-dihydrohelvolic acid (8) were also identified. One-dimensional (1D), two-dimensional (2D) NMR, HRMS, and circular dichroism spectral analysis characterized the structures of the isolated compounds.

SUBMITTER: Xu X

PROVIDER: S-EPMC6562449 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Two New Spiro-Heterocyclic γ-Lactams from A Marine-Derived Aspergillus fumigatus Strain CUGBMF170049.

Xu Xiuli X Han Jiahui J Wang Yanan Y Lin Rui R Yang Haijin H Li Jiangpeng J Wei Shangzhu S Polyak Steven W SW Song Fuhang F

Marine drugs 20190514 5

Two new spiro-heterocyclic γ-lactam derivatives, cephalimysins M (1) and N (2), were isolated from the fermentation cultures of the marine-derived fungus Aspergillus fumigatus CUGBMF17018. Two known analogues, pseurotin A (3) and FD-838 (4), as well as four previously reported helvolic acid derivatives, 16-O-propionyl-16-O-deacetylhelvolic acid (5), 6-O-propionyl-6-O-deacetylhelvolic acid (6), helvolic acid (7 ...[more]

PMID: 31091673

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